| Home Team | Home Pitcher | Visiting Team | Visiting Pitcher | Date/Time | Notes |
|---|---|---|---|---|---|
| Spartanburg | Woodmont | 04/26 06:30 PM | |||
| Summerville | Fort Dorchester | 04/26 07:00 PM | |||
| James Island Trojans | West Ashley Wildcats | 04/26 06:30 PM | |||
| Dutch Fork | Lexington | 04/26 06:30 PM | |||
| West-Oak | Liberty | 04/26 06:30 PM | |||
| Airport | Cardinal Newman | 04/26 07:00 PM | |||
| Hillcrest | TL Hanna | 04/26 06:30 PM | |||
| Wando | Lucy Beckham | 04/26 06:00 PM | |||
| Greenville | Wren | 04/26 07:00 PM | |||
| Stratford (12-13) | Bryce Herpolsheimer (1-2) | Carolina Forest (10-12) | Nolan Alexander (4-2) | 04/30 06:30 PM | 5A Lower State Playoffs |
| Laurens | Northwestern | 04/29 12:00 AM | 4A Upper State Playoffs | ||
| Greenwood | Midland Valley | 04/29 12:00 AM | 4A Upper State Playoffs | ||
| North Augusta | Greenville | 04/29 12:00 AM | 4A Upper State Playoffs | ||
| Catawba Ridge | Eastside | 04/29 12:00 AM | 4A Upper State Playoffs | ||
| Airport | Westside | 04/29 12:00 AM | 4A Upper State Playoffs | ||
| Riverside | Indian Land | 04/29 12:00 AM | 4A Upper State Playoffs | ||
| Easley | Aiken | 04/29 12:00 AM | 4A Upper State Playoffs | ||
| Greer | Lancaster | 04/29 12:00 AM | 4A Upper State Playoffs | ||
| North Myrtle Beach | At Large | 04/29 12:00 AM | 4A Lower State Playoffs | ||
| Lucy Beckham | Myrtle Beach | 04/29 06:30 PM | 4A Lower State Playoffs | ||
| May River | Myrtle Beach | 04/29 12:00 AM | 4A Lower State Playoffs | ||
| AC Flota | At Large | 04/29 12:00 AM | 4A Lower State Playoffs | ||
| James Island | At Large | 04/29 12:00 AM | 4A Lower State Playoffs | ||
| Hartsville | Westwood | 04/29 12:00 AM | 4A Lower State Playoffs | ||
| Lugoff-Elgin | At Large | 04/29 12:00 AM | 4A Lower State Playoffs | ||
| West Florence | Hilton Head | 04/29 12:00 AM | 4A Lower State Playoffs | ||
| Crescent | Broome | 04/30 12:00 AM | 3A Upper State Playoffs | ||
| Region 4 #2 | Fountain Inn | 04/30 12:00 AM | 3A Upper State Playoffs | ||
| Wren | Region 4 #1 | 04/30 12:00 AM | 3A Upper State Playoffs | ||
| Daniel | Travelers Rest | 04/30 12:00 AM | 3A Upper State Playoffs | ||
| Blue Ridge | Pendleton | 04/30 12:00 AM | 3A Upper State Playoffs | ||
| Emerald | Powdersville | 04/30 12:00 AM | 3A Upper State Playoffs | ||
| Chapman | Seneca | 04/30 12:00 AM | 3A Upper State Playoffs | ||
| Gilbert | Lake City | 04/30 12:00 AM | 3A Lower State Playoffs | ||
| Region 8 #2 | Georgetown | 04/30 12:00 AM | 3A Lower State Playoffs | ||
| Camden | Orangeburg-Wilkinson | 04/30 12:00 AM | 3A Lower State Playoffs | ||
| Loris | Region 8 #3 | 04/30 12:00 AM | 3A Lower State Playoffs | ||
| Hanahan | Aynor | 04/30 12:00 AM | 3A Lower State Playoffs | ||
| Dreher | Darlington | 04/30 12:00 AM | 3A Lower State Playoffs | ||
| Waccamaw | Battery Creek | 04/30 12:00 AM | 3A Lower State Playoffs | ||
| Marlboro County | Brookland-Cayce | 04/30 12:00 AM | 3A Lower State Playoffs | ||
| TL Hanna | Rock Hill | 04/30 12:00 AM | 5A Upper State Playoffs | ||
| Lexington | Dorman/Spartanburg | 04/30 12:00 AM | 5A Upper State Playoffs | ||
| Fort Mill | Woodmont | 04/30 12:00 AM | 5A Upper State Playoffs | ||
| Boiling Springs | River Bluff/Dutch Fork | 04/30 12:00 AM | 5A Upper State Playoffs | ||
| Blythewood | Dorman/Spartanburg | 04/30 12:00 AM | 5A Upper State Playoffs | ||
| Hillcrest | Nation Ford | 04/30 12:00 AM | 5A Upper State Playoffs | ||
| Byrnes | At Large | 04/30 12:00 AM | 5A Upper State Playoffs | ||
| JL Mann | Clover | 04/30 12:00 AM | 5A Upper State Playoffs | ||
| Chapin | Cane Bay | 04/30 12:00 AM | 5A Lower State Playoffs | ||
| West Ashley | Conway | 04/30 12:00 AM | 5A Lower State Playoffs | ||
| Wando | Dutch Fork/River Bluff | 04/30 12:00 AM | 5A Lower State Playoffs | ||
| Sumter | Ashley Ridge | 04/30 12:00 AM | 5A Lower State Playoffs | ||
| Summerville | At Large | 04/30 12:00 AM | 5A Lower State Playoffs | ||
| St. James | At Large | 04/30 12:00 AM | 5A Lower State Playoffs | ||
| Chesnee | Chesnee | 04/30 12:00 AM | 2A Upper State Playoffs | ||
| Strom Thurmond | Keenan | 04/30 12:00 AM | 2A Upper State Playoffs | ||
| Mid-Carolina | Pelion | 04/30 12:00 AM | 2A Upper State Playoffs | ||
| Fairfield Central | Landrum | 04/30 12:00 AM | 2A Upper State Playoffs | ||
| Fox Creek | Eau Claire | 04/30 12:00 AM | 2A Upper State Playoffs | ||
| Blacksburg | Abbeville | 04/30 12:00 AM | 2A Upper State Playoffs | ||
| Gray Collegiate | Liberty | 04/30 12:00 AM | 2A Upper State Playoffs | ||
| Saluda | Batesburg-Leesville | 04/30 12:00 AM | 2A Upper State Playoffs | ||
| Buford/Cheraw | Hampton County | 04/30 12:00 AM | 2A Lower State Playoffs | ||
| Bishop England | Lee Central | 04/30 12:00 AM | 2A Lower State Playoffs | ||
| Barnwell | Timberland | 04/30 12:00 AM | 2A Lower State Playoffs | ||
| Marion/Andrew | Andrew Jackson/North Central | 04/30 12:00 AM | 2A Lower State Playoffs | ||
| Oceanside Collegiate | Mullins | 04/30 12:00 AM | 2A Lower State Playoffs | ||
| Buford/Cheraw | Woodland | 04/30 12:00 AM | 2A Lower State Playoffs | ||
| Andrew/Marion | North Central/Andrew Jackson | 04/30 12:00 AM | 2A Lower State Playoffs | ||
| Edisto | Academic Magnet | 04/30 12:00 AM | 2A Lower State Playoffs | ||
| Southside Christian | Waegener-Salley | 04/30 12:00 AM | 1A Upper State Playoffs | ||
| Lewisville | Whitmire | 04/30 12:00 AM | 1A Upper State Playoffs | ||
| Ware Shoals | CA Johnson | 04/30 12:00 AM | 1A Upper State Playoffs | ||
| Calhoun County | St. Joseph's | 04/30 12:00 AM | 1A Upper State Playoffs | ||
| Thornwell | McBee | 04/30 12:00 AM | 1A Upper State Playoffs | ||
| Christ Church | North | 04/30 12:00 AM | 1A Upper State Playoffs | ||
| Williston-Elko | Brashier Middle College | 04/30 12:00 AM | 1A Upper State Playoffs | ||
| Dixie | Great Falls | 04/30 12:00 AM | 1A Upper State Playoffs | ||
| East Clarendon | Region 8 #4 | 04/30 12:00 AM | 1A Lower State Playoffs | ||
| Bridges Prep/Branchville | Hannah-Pamplico | 04/30 12:00 AM | 1A Lower State Playoffs | ||
| Lake View | Whale Branch | 04/30 12:00 AM | 1A Lower State Playoffs | ||
| St. Johns/Lowcountry Leadership | Carvers Bay | 04/30 12:00 AM | 1A Lower State Playoffs | ||
| Bamberg-Erhardt | Latta | 04/30 12:00 AM | 1A Lower State Playoffs | ||
| Johnsonville | Charleston M&S | 04/30 12:00 AM | 1A Lower State Playoffs | ||
| St. John's/Lowcountry Leadership | Hemingway | 04/30 12:00 AM | 1A Lower State Playoffs | ||
| Green-Sea Floyd's | Branchville/Bridges Prep | 04/30 12:00 AM | 1A Lower State Playoffs | ||
| Berkeley | Fort Dorchester | 04/30 12:00 AM | 5A Lower State Playoffs | ||
| Clinton | Carson Glenn | Union County | Tanner Hardin | 04/26 06:30 PM |
